IMMUNOGLOBULIN CHIMERIC MONOMER-DIMER HYBRIDS

The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain c...

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Bibliographische Detailangaben
Hauptverfasser: MEZO, Adam R, PETERS, Robert T, BITONTI, Alan J, RIVERA, Daniel S, LOW, Susan C
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.