INHIBITORS OF THE MENIN-MLL INTERACTION

INHIBITORS OF THE MENIN-MLL INTERACTION

The present disclosure is directed to inhibitors of Formula (0), or a stereoisomer thereof, or pharmaceutically acceptable salt thereof, of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other d...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CACATIAN, Salvacion, SAMANTA, Swapan Kumar, MILLER, William H, REDDY, Virsinha Venkat, CAMP, Nicholas Paul, MCGEEHAN, Gerard M, KULKARNI, Santosh S
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure is directed to inhibitors of Formula (0), or a stereoisomer thereof, or pharmaceutically acceptable salt thereof, of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.