Application identity-based enforcement of datagram protocols

Systems and methods include obtaining telemetry from a plurality of security agents each operating on a device in a network, wherein the telemetry is collected locally related to datagram protocol packets; analyzing the telemetry to determine applications associated with the datagram protocol packets flowing in the network and virtual circuits between each of the applications; determining enforcement policies for each application that communicates with other applications over a datagram protocol; and providing the enforcement policies to the plurality of security agents for allowing and blocking communications associated with the datagram protocol.