CRYSTALLINE FORM OF ACETYLCHOLINESTERASE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

CRYSTALLINE FORM OF ACETYLCHOLINESTERASE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The present invention provides a crystalline form of an acetylcholinesterase inhibitor, a preparation method therefor and application thereof. Specifically, the crystalline form is crystalline form A, crystalline form B and crystalline form C of 2-((1-(2-fluorobenzyl)-4-fluoropiperidin-4-yl) methyle...

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Bibliographische Detailangaben
Hauptverfasser: FU, Yan, TANG, Xican, CHEN, Kaixian, ZHOU, Yu, LI, Jian, LIU, Hong, JIANG, Hualiang, ZHANG, Haiyan
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides a crystalline form of an acetylcholinesterase inhibitor, a preparation method therefor and application thereof. Specifically, the crystalline form is crystalline form A, crystalline form B and crystalline form C of 2-((1-(2-fluorobenzyl)-4-fluoropiperidin-4-yl) methylene)-5, 6-dimethoxy-2, 3-dihydro-1-indanone. The crystalline form of the present invention does not contain water and solvent, has high stability and low hygroscopicity, is easy to process, and is very suitable for preparing drugs for preventing and/or treating neurodegenerative diseases.