COCRYSTALS OF STEROID AND SECOSTEROID COMPOUNDS AND COMPOSITIONS COMPRISING THEM

It is provided a cocrystal of a compound of formula (I) or of a compound formula (II) wherein X and Y are independently selected from -CH2- and -C(CH2)-, provided that al least one of X or Y is -CH2-; R1 is -CHCH3-Zm-Wn-(CH2)o-Tp-S, wherein Z is O, and m is 0 or 1; W is R4CH CHR5, wherein either R4...

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Bibliographische Detailangaben
Hauptverfasser: DE SANDE LÓPEZ, Dafne, BARBAS CAÑERO, Rafael, PROHENS LÓPEZ, Rafel, BOFILL HERRERA, Lidia
Format: Patent
Sprache:eng
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Zusammenfassung:It is provided a cocrystal of a compound of formula (I) or of a compound formula (II) wherein X and Y are independently selected from -CH2- and -C(CH2)-, provided that al least one of X or Y is -CH2-; R1 is -CHCH3-Zm-Wn-(CH2)o-Tp-S, wherein Z is O, and m is 0 or 1; W is R4CH CHR5, wherein either R4 and R5 are H and the dashed line indicates that there is a single bond, or R4 and R5 together are forming a bond and the dashed line indicates that there is a double bond, and n is 0 or 1; o is 0, 1 or 3; T is selected from the group consisting of -CHR6-, -C(O), wherein R6 is -OH or -CH3, and p is 0 or 1; S is selected from the group consisting of H, (C1-C3) alkyl optionally substituted by -OH, (C1-C3) haloalkyl optionally substituted by -OH, cyclopropyl, or; and R2 is -H or -OH; R3 is H or CH3; and the dashed line in formula (II) indicates a single or a double bond; and a hydrogen bond donor coformer which is a phenolic compound. It is also provided a composition comprising the cocrystal and a personal care product comprising the composition.