PURINE DERIVATIVE AND MEDICAL USE THEREOF

The present invention relates to a purine derivative and use thereof in medicine, and in particular to a pyrimidine derivative shown as general formula (I) or a stereoisomer, solvate, metabolite, prodrug, deuteride, pharmaceutically acceptable salt or cocrystal thereof, a pharmaceutical composition...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wang, Meiwei, Xu, Xuezhen, Chu, Hongzhu, He, Lvxue, Sun, Yi, Wei, Yonggang, Su, Guizhuan, Meng, Xiangyu, Liu, Bing
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to a purine derivative and use thereof in medicine, and in particular to a pyrimidine derivative shown as general formula (I) or a stereoisomer, solvate, metabolite, prodrug, deuteride, pharmaceutically acceptable salt or cocrystal thereof, a pharmaceutical composition comprising the same, and use of the compound or composition of the present invention in the field of preparation of a DNA-PK inhibitor, wherein the substituents in general formula (I) are defined in the same way as in the specification