Interface Module with Low-Latency Communication of Electrical Signals Between Power Domains

An integrated circuit is described. This integrated circuit may include: an interface module with a first power domain and a second power domain. The first power domain may include a digital controller, and the second power domain may include a first analog front end (AFE) circuit. Moreover, the interface module may include up/down level shifters that communicate electrical signals that include a DC component from the first power domain to the second power domain. In some embodiments, the integrated circuit may provide a fully on-chip solution to handle level shifting between the AFE circuit and a digital controller in Universal Serial Bus (USB) 2.0 during communication of electrical signals in a full-speed mode and/or a high-speed mode.