Novel Ferroportin Inhibitors

The invention relates to novel compounds of the general formula (I),with Het-2 being an optionally substituted bicyclic heteroaryl of the formulapharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Pena, Paula, Dürrenberger, Franz, Shepherd, Jon, Scott, John, Burgert, Michael, Manolova, Vania, Boyce, Susan, Yarnold, Christopher John, Kalogerakis, Aris, Burckhardt, Susanna, Lecci, Cristina, Buhr, Wilm, Jarjes-Pike, Richard, Reim, Stefan
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to novel compounds of the general formula (I),with Het-2 being an optionally substituted bicyclic heteroaryl of the formulapharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.