ANTI-CXCR2 ANTIBODIES AND USES THEREOF

Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers....

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Bibliographische Detailangaben
Hauptverfasser: Pollard, Matthew, Cooksey, Bridget Ann, Shim Siew Chen, Doris, Poulton, Lynn Dorothy, Laine, David Jose Simon, Clarke, Adam, Doyle, Anthony, Gill, Jason William
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.