ANTIBODY-DRUG CONJUGATES THAT TARGET DLK1 AND USES THEREOF

ANTIBODY-DRUG CONJUGATES THAT TARGET DLK1 AND USES THEREOF

The present invention relates to new antibody-drug conjugates (ADCs) targeting DLK1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of...

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Hauptverfasser: Jang, Tae Ik, Park, Bum-Chan, Lee, Hyeun Joung, Choi, Yunseon, Kim, Sung Min, Park, Chang Sik, Kim, Hyoung Rae, Kim, Yong Zu, Lee, Sang Pil, Park, Yun-Hee, Park, Jae Eun, Park, Young Woo, Chae, Jeiwook, Lee, Chang Sun, Shin, Ji-Young, Baek, Ju Yuel, Lee, Ju Young, Yoon, Sunha, Choi, Min Ji, Lee, Kun Jung, Song, Ho Young, Lee, Jisu
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to new antibody-drug conjugates (ADCs) targeting DLK1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically, uses for such ADCs in producing drugs for treatment and/or prevention of proliferative and/or angiogenetic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding with DLK1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.