CA2-IL15 FUSION PROTEINS FOR TUNABLE REGULATION

The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (EL15) payloads, as well as compositions and methods of use thereof.

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Bibliographische Detailangaben
Hauptverfasser:	FOLEY, Colleen, EZELL, Tucker Read, SUBRAMANIAN, Shyamsundar, ELPEK, Kutlu Goksu, STORER, James A, SUN, Dexue, MYLVAGANAM, Geetha Hanna, SETHI, Dhruv Kam, LANGLEY, Meghan C, PERKINS, Molly Reed, RICHARDSON, Celeste, OLS, Michelle, FLEURY, Michelle, TCHAICHA, Jeremy Hatem, GORI, Jennifer Leah, HELLER, Scott Francis, SURI, Vipin
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (EL15) payloads, as well as compositions and methods of use thereof.