CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

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Hauptverfasser: LI, Wenjun, GAI, Shun, GUO, Zhixiang, HUANG, Yuanyuan, YANG, Yanlei, YE, Zhichang, ZHU, Haifeng, JIA, Junxiang, YANG, Qingliang, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, LI, Chen, YANG, Chengyu, GAO, Shuihong, CAO, Minjun, ZHAO, Yongxin Robert, WANG, Chunyan, TONG, Qianqian, ZHAO, Linyao, XIE, Hongsheng, YE, Hangbo, BAI, Lu
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator LI, Wenjun
GAI, Shun
GUO, Zhixiang
HUANG, Yuanyuan
YANG, Yanlei
YE, Zhichang
ZHU, Haifeng
JIA, Junxiang
YANG, Qingliang
ZHOU, Xiaomai
GUO, Huihui
XU, Yifang
LI, Chen
YANG, Chengyu
GAO, Shuihong
CAO, Minjun
ZHAO, Yongxin Robert
WANG, Chunyan
TONG, Qianqian
ZHAO, Linyao
XIE, Hongsheng
YE, Hangbo
BAI, Lu
description The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS
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