CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

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Bibliographische Detailangaben
Hauptverfasser: LI, Wenjun, GAI, Shun, GUO, Zhixiang, HUANG, Yuanyuan, YANG, Yanlei, YE, Zhichang, ZHU, Haifeng, JIA, Junxiang, YANG, Qingliang, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, LI, Chen, YANG, Chengyu, GAO, Shuihong, CAO, Minjun, ZHAO, Yongxin Robert, WANG, Chunyan, TONG, Qianqian, ZHAO, Linyao, XIE, Hongsheng, YE, Hangbo, BAI, Lu
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.