PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES

PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES

The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties. The present disclosure also relates to methods of using these conjugates, e.g., as therapeutics and/or diagnostics.

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Bibliographische Detailangaben
Hauptverfasser: KELLEHER, Eugene W, THOMAS, Joshua D, YURKOVETSKIY, Aleksandr V, JONES, Brian D, YIN, Mao, LOWINGER, Timothy B, YANG, Liping
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
COMPOUNDS OF UNKNOWN CONSTITUTION
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties. The present disclosure also relates to methods of using these conjugates, e.g., as therapeutics and/or diagnostics.