KINASE ACTIVITY SIGNATURES FOR PREDICTING THE RESPONSE OF NON-SMALL-CELL LUNG CARCINOMA PATIENTS TO A PD-1 OR PD-L1 IMMUNE CHECKPOINT INHIBITOR

The present invention relates to a method for determining or predicting the response of a patient diagnosed with non-small-cell lung carcinoma a PD-1 or PD-L1 immune checkpoint inhibitor. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed...

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Bibliographische Detailangaben
Hauptverfasser:	DE WIJN, Richard, VAN DEN HEUVEL, Dirgje Maria Adriana
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a method for determining or predicting the response of a patient diagnosed with non-small-cell lung carcinoma a PD-1 or PD-L1 immune checkpoint inhibitor. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with non-small-cell lung carcinoma to PD-1 or PD-L1 immune checkpoint inhibitors. More specifically, the present invention provides methods which measure kinase-activity and profiles and inhibitions thereof by drugs in blood samples of said patients.