STERIC EPITOPE OF CEACAM1, AND ANTI-CEACAM1 ANTIBODY, OR FRAGMENT THEREOF, THAT SPECIFICALLY BINDS TO SAME

STERIC EPITOPE OF CEACAM1, AND ANTI-CEACAM1 ANTIBODY, OR FRAGMENT THEREOF, THAT SPECIFICALLY BINDS TO SAME

A steric epitope of CEACAM1 is disclosed. An anti-CEACAM1 antibody or a fragment thereof, which specifically binds to CEACAM1 is disclosed. A steric epitope of CEACAM1 includes all amino acids in critical positions for specific binding to an anti-CEACAM1 antibody and maintains an appropriate three-d...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: OH, Mi-Young, PARK, Hye Young, YUM, Hye In, KIM, Dong-Sik, LEE, Jae-Chul
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A steric epitope of CEACAM1 is disclosed. An anti-CEACAM1 antibody or a fragment thereof, which specifically binds to CEACAM1 is disclosed. A steric epitope of CEACAM1 includes all amino acids in critical positions for specific binding to an anti-CEACAM1 antibody and maintains an appropriate three-dimensional structure, and thus can high affinity for an anti-CEACAM1 antibody. In addition, an antibody, or a fragment thereof, that specifically binds to a steric epitope can effectively suppress CEACAM1-CEACAM1 interaction and CEACAM1-CEACAM6 interaction.