Targeted Lung Denervation with Directionally-Adjustable Perfusion

A lung denervation method comprises advancing a catheter along the airway; deploying an open loop in contact with the epithelium; simultaneously delivering radio frequency energy from a plurality of discrete spaced-apart locations along the loop to target regions according to a set of ablation param...

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Hauptverfasser: Keast, Thomas M, QIN, Xiangxiang, LIU, Zhiyu, CUI, Changjie, XU, Hong
Format: Patent
Sprache:eng
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Zusammenfassung:A lung denervation method comprises advancing a catheter along the airway; deploying an open loop in contact with the epithelium; simultaneously delivering radio frequency energy from a plurality of discrete spaced-apart locations along the loop to target regions according to a set of ablation parameters sufficient to heat and interrupt nerve functionality; and forming a liquid film between the loop and the epithelium for minimizing collateral damage. The method serves to destroy motor axons of the peripheral bronchial nerve, blocks parasympathetic transmission in the pulmonary and reduces acetylcholine release, reducing airway smooth muscle tension and mucus production. Related systems are described.