FLUID ANALYSES AND SENSOR CONSTRUCTS EMPLOYING HEXASUBSTITUTED BENZENES

Phenyl rings provide a robust scaffold for molecular design, given the limited number of ring carbon atoms and the fixed geometry in between. Alternating groups in hexasubstituted benzenes may be directed toward opposite faces of the phenyl ring, such that orthogonal reactive groups are directed toward the opposite faces for promoting both surface attachment and introduction of functionalities suitable for promoting analyte detection. Hexasubstituted benzenes capable of covalent bonding to a surface and having functionalities capable of promoting detection of one or more analytes in fluids may be realized. An analytical response of the hexasubstituted benzenes or a change thereof may be correlated to an amount of at least one analyte present in a fluid, including both single- and multi-phase complex fluids.