METHOD FOR CONTINUOUSLY PRODUCING AN ACTIVE INGREDIENT GRANULATE

A method for the continuous production of an active ingredient granulate is provided, which comprises the following steps:(a) preparing a spray composition by dissolving or dispersing an active ingredient and optionally one or more excipients in a liquid;(b) providing solid particles in a process sp...

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Bibliographische Detailangaben
Hauptverfasser: NOWAK, Reinhard, GRAVE, Annette, PÖLLINGER, Norbert, JACOB, Michael
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A method for the continuous production of an active ingredient granulate is provided, which comprises the following steps:(a) preparing a spray composition by dissolving or dispersing an active ingredient and optionally one or more excipients in a liquid;(b) providing solid particles in a process space;(c) introducing droplets of the spray composition into an injection zone of the process space in which the liquid evaporates;(d) repeatedly guiding the solid particles back past the sprayed droplets in the process space with the aid of a process gas jet, so that at least a portion of the droplets, which may have already lost part of the liquid contained, comes into contact with solid particles and larger solid particles are formed through agglomeration;(e) removing the active ingredient granulate from the process space in the form of solid particles,wherein the active ingredient in the form used has a Hausner factor of 1.19 or greater.