Indicators for Confirming Fluid Connections in Systems, Pads, and Methods for Targeted Temperature Management

Disclosed are indicators for confirming fluid connections in systems, pads, and methods thereof for targeted temperature management. For example, a pad can include a multilayered pad body, a pad inlet connector, a pad outlet connector, and an indicator for visual indication of charging a conduit layer of the pad body with a supply fluid and confirmation of accurate fluid connections. The conduit layer includes one or more conduits for conveying a temperature-controlled fluid as the supply fluid from a hydraulic system of a control module as well as convey a return fluid back to the hydraulic system. A thermally conductive adhesive layer over the conduit layer is for placement on a portion of a patient's body. The pad inlet connector includes a pad inlet for charging the conduit layer with the supply fluid. The pad outlet connector includes a pad outlet for discharging the return fluid from the conduit layer.