MULTISPECIFIC ANTIBODY CONSTRUCTS

MULTISPECIFIC ANTIBODY CONSTRUCTS

The present disclosure relates to a multi-specific antibody molecule comprising or consisting of a) a polypeptide chain of formula (I): VH-CH1-X-V1; and b) a polypeptide chain of formula (II): VL-CL-Y-V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure als...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Humphreys, David Paul, Bhatta, Pallavi, Heywood, Sam Philip, Dave, Emma
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present disclosure relates to a multi-specific antibody molecule comprising or consisting of a) a polypeptide chain of formula (I): VH-CH1-X-V1; and b) a polypeptide chain of formula (II): VL-CL-Y-V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.