11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN

11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN

Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Delwig, Anton, Pajouhesh, Hassan, Du Bois, Justin, Shibuya, Grant Masaaki, Beckley, Jacob, Mulcahy, John, Miljanich, George
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.