Multispecific Antigen-Binding Molecules for Cell Targeting and Uses Thereof

Multispecific Antigen-Binding Molecules for Cell Targeting and Uses Thereof

The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Haber, Lauric, Finney, Jennifer A, Smith, Eric, Lin, Chia-Yang, McKay, Ryan
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.