COMBINED THERAPIES OF ACTIVATABLE IMMUNE CHECKPOINT INHIBITORS AND CONJUGATED ACTIVATABLE ANTIBODIES

COMBINED THERAPIES OF ACTIVATABLE IMMUNE CHECKPOINT INHIBITORS AND CONJUGATED ACTIVATABLE ANTIBODIES

Provided herein are compositions and methods relating to therapies that combine a conjugated activatable anti-CD 166 antibody that when activated specifically binds to CD 166 and an activatable immune checkpoint inhibitor. Also provided herein are compositions and methods relating to therapies that...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tse, Tiffany, Le Scolan, Erwan, Krimm, Michael A, Garner, Will
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein are compositions and methods relating to therapies that combine a conjugated activatable anti-CD 166 antibody that when activated specifically binds to CD 166 and an activatable immune checkpoint inhibitor. Also provided herein are compositions and methods relating to therapies that combine an activatable anti-immune checkpoint antibody that when activated specifically binds to the immune checkpoint and a conjugated activatable antibody, where the immune checkpoint is mammalian PD-1 or mammalian PD-L1.