AGENTS MODULATING BETA-CATENIN FUNCTIONS AND METHODS THEREOF

AGENTS MODULATING BETA-CATENIN FUNCTIONS AND METHODS THEREOF

Among other things, the present disclosure provides technologies for modulating functions of beta-catenin. In some embodiments, the present disclosure provides stapled peptides that interact with beta-catenin. In some embodiments, provided stapled peptides interact with beta-catenin at an Axin-bindi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: McGee, John Hanney, Verdine, Gregory L, Shim, So Youn, Ortet, Paula Cristina, Hilinski, Gerard, Patton, Matthew Reiser
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Among other things, the present disclosure provides technologies for modulating functions of beta-catenin. In some embodiments, the present disclosure provides stapled peptides that interact with beta-catenin. In some embodiments, provided stapled peptides interact with beta-catenin at an Axin-binding site of beta-catenin. In some embodiments, the present disclosure provides compounds, compositions and methods for preventing and/or treating conditions, disorders and diseases that are associated with beta-catenin.