Novel Substituted N-(3-Fluoropropyl)-Pyrrolidine Compounds, Processes for their Preparation and Therapeutic Uses Thereof

Novel Substituted N-(3-Fluoropropyl)-Pyrrolidine Compounds, Processes for their Preparation and Therapeutic Uses Thereof

The present invention relates to novel substituted N-(3-fluoropropyl)-pyrrolidine compounds of formula (I-A):wherein R1 and R2 represent independently a hydrogen atom or a deuterium atom; A represents an oxygen or nitrogen atom; and SERM-F represents a selective estrogen receptor modulator fragment...

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Bibliographische Detailangaben
Hauptverfasser: TABART, Michel, SCHIO, Laurent, BOUABOULA, Monsif, CERTAL, Victor, FILOCHE-ROMME, Bruno, THOMPSON, Fabienne, EL-AHMAD, Youssef, BROLLO, Maurice, TERRIER, Corinne, MCCORT, Gary, HALLEY, Frank
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to novel substituted N-(3-fluoropropyl)-pyrrolidine compounds of formula (I-A):wherein R1 and R2 represent independently a hydrogen atom or a deuterium atom; A represents an oxygen or nitrogen atom; and SERM-F represents a selective estrogen receptor modulator fragment comprising an aryl or heteroaryl group linked to the adjacent "A" group.The invention also relates to the preparation and to the therapeutic uses of the compounds of formula (I-A) as inhibitors and degraders of estrogen receptors.