SELF-ASSEMBLING PROTEIN NANOCAGE DECORATED WITH ANTIBODIES (SAPNA) AND PARTS THEREOF

SELF-ASSEMBLING PROTEIN NANOCAGE DECORATED WITH ANTIBODIES (SAPNA) AND PARTS THEREOF

The present invention provides for a protein cage polypeptide (or scaffolding protein) useful or capable of forming a hollow tetrahedral pyramid structure, and a "self-assembling protein nanoparticle decorated with antibodies" (SAPNA) which is a chimeric protein assembly comprising: (a) on...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hura, Gregory L, Hodge, Curtis D, Yeates, Todd O
Format: Patent
Sprache:eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:The present invention provides for a protein cage polypeptide (or scaffolding protein) useful or capable of forming a hollow tetrahedral pyramid structure, and a "self-assembling protein nanoparticle decorated with antibodies" (SAPNA) which is a chimeric protein assembly comprising: (a) one or more antibodies and (b) the protein cage polypeptide that provides a scaffold upon which to array the antibodies. In some embodiments, the antibody is capable of binding specifically to a pathogenic biological agent, or part thereof.