METHOD OF PREPARING NANOPLATEFORM-BASED DIAGNOSTIC AGENT FOR SELECTIVELY STAINING OF INFLAMMATORY ABNORMAL TISSUE OR TUMOR TISSUE

The present invention relates to a method for preparing a nano diagnostic agent capable of selective staining of abnormal inflammatory tissues or tumor tissues. The method for preparing a nano diagnostic agent, according to the present invention, is characterized by comprising: a step of forming a f...

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Bibliographische Detailangaben
Hauptverfasser: HWANG, Chang Soon, CHO, Han Weon, OH, Keun Sang, KIM, Sun Jong, LEE, Hye Jin, CHUNG, Hye Sook
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a method for preparing a nano diagnostic agent capable of selective staining of abnormal inflammatory tissues or tumor tissues. The method for preparing a nano diagnostic agent, according to the present invention, is characterized by comprising: a step of forming a first mixture by mixing polysorbate 80, soybean oil, and a water-insoluble staining material; a step of forming a second mixture by mixing and then heating the first mixture and a triblock copolymer; a step of forming a nano platform solid by cooling the second mixture; a step of forming a third mixture by mixing a solvent with the nano platform solid; a step of removing impurities from the third mixture; and a step of forming a nano-composite by freeze-drying the third mixture from which the impurities are removed. Thereby, the present invention can increase the search efficiency of a disease lesion by being transmitted through micropores of a tumor through direct permeation and absorption so as to precisely distinguish normal tissues from abnormal tissues.