METHODS AND SYSTEMS FOR DETECTING GENETIC FUSIONS TO IDENTIFY A LUNG DISORDER

Gene fusions are hybrid genes formed by two previously separate genes. Many such gene fusions may be strong driver mutations for cancer and may play important roles in tumorigenesis. Gene fusions may be identified in biological samples extracted from the diseased location. However, for lung cancer,...

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Hauptverfasser:	Hao, Yangyang, Huang, Jing, Kennedy, Giulia C, Walsh, Patric Sean, Babiarz, Joshua
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Gene fusions are hybrid genes formed by two previously separate genes. Many such gene fusions may be strong driver mutations for cancer and may play important roles in tumorigenesis. Gene fusions may be identified in biological samples extracted from the diseased location. However, for lung cancer, extracting samples from the nodules may be challenging and may lead to undesirable consequences. Disclosed herein is a method and system of identifying a gene fusion landscape from bronchial brushings and further identifying fusions that may be potentially associated with lung cancer.