A SUSTAINED RELEASE COMPOSITION COMPRISING A HYDROXYALKYL METHYLCELLULOSE

A SUSTAINED RELEASE COMPOSITION COMPRISING A HYDROXYALKYL METHYLCELLULOSE

A sustained release composition for oral administration comprises particles of a physiologically active ingredient mixed with a hydroxyalkyl methylcellulose, wherein the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl,the hydroxyalky...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: Petermann, Oliver
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A sustained release composition for oral administration comprises particles of a physiologically active ingredient mixed with a hydroxyalkyl methylcellulose, wherein the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl,the hydroxyalkyl methylcellulose has an MS(hydroxyalkyl) of 0.05 to 1.00, and hydroxy groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.30 or less, andwherein the concentration of hydroxyalkyl methylcellulose is 0.1-10% by dry weight of the active ingredient.