INHIBITORS OF JUN N-TERMINAL KINASE

The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula:or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compo...

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Hauptverfasser:	PROBST, Gary D, SEALY, Jennifer, NEITZ, R. Jeffrey, KONRADI, Andrei W, TOTH, Gergely, SHAM, Hing L, HOM, Roy K, BOWERS, Simeon, TRUONG, Anh
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Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	PROBST, Gary D SEALY, Jennifer NEITZ, R. Jeffrey KONRADI, Andrei W TOTH, Gergely SHAM, Hing L HOM, Roy K BOWERS, Simeon TRUONG, Anh
description	The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula:or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
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Jeffrey</au><au>KONRADI, Andrei W</au><au>TOTH, Gergely</au><au>SHAM, Hing L</au><au>HOM, Roy K</au><au>BOWERS, Simeon</au><au>TRUONG, Anh</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBITORS OF JUN N-TERMINAL KINASE</title><date>2022-03-17</date><risdate>2022</risdate><abstract>The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula:or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.</abstract><oa>free_for_read</oa></addata></record>
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title	INHIBITORS OF JUN N-TERMINAL KINASE
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