INHIBITORS OF JUN N-TERMINAL KINASE

INHIBITORS OF JUN N-TERMINAL KINASE

The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula:or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PROBST, Gary D, SEALY, Jennifer, NEITZ, R. Jeffrey, KONRADI, Andrei W, TOTH, Gergely, SHAM, Hing L, HOM, Roy K, BOWERS, Simeon, TRUONG, Anh
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula:or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.