PHARMACEUTICAL COMPOSITIONS FOR USE IN TREATING PAIN

Provided is a pharmaceutical composition for use in treating postsurgical pain. The pharmaceutical composition comprises a lipid-based complex. The lipid-based complex comprises an amide-type anesthetic and at least one lipid, wherein a molar ratio of the amide-type anesthetic to the at least one li...

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Hauptverfasser: TSENG, YUN-LONG, KAO, HAO-WEN, BROWN, CARL OSCAR, WANG, HUI-TING, JAO, WEENEE YEUN NG, TAI, TIEN-TZU, HU, PEI-HSIEN, SHIH, SHEUE-FANG, YU, WAN-NI, LIN, YI-YU, HONG, KEELUNG, KUO, MIN-WEN
Format: Patent
Sprache:eng
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Zusammenfassung:Provided is a pharmaceutical composition for use in treating postsurgical pain. The pharmaceutical composition comprises a lipid-based complex. The lipid-based complex comprises an amide-type anesthetic and at least one lipid, wherein a molar ratio of the amide-type anesthetic to the at least one lipid of the lipid-based complex is at least 0.5:1. The total amount of the amide-type anesthetic is at least 1.5 to 5 times of a standard therapeutic dose for treating postsurgical pain with the amide-type anesthetic to achieve an improved pain control with desired prolonged analgesic effect.