Pantoprazole Compositions and Methods

A spray-dried storage stable pantoprazole composition is provided. The pantoprazole composition includes a pantoprazole and an excipient matrix including sodium chloride (NaCl). The pantoprazole is substantially uniformly dispersed in the excipient matrix. A method for forming a storage stable panto...

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Hauptverfasser: Jagadale, Govind R, Chodavarapu, Bala Tripura Sundari, Shukla, Anand, Lakkaraju, Dasaradhi, Pandya, Brijeshkumar B, Shukla, Jwalant
Format: Patent
Sprache:eng
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Zusammenfassung:A spray-dried storage stable pantoprazole composition is provided. The pantoprazole composition includes a pantoprazole and an excipient matrix including sodium chloride (NaCl). The pantoprazole is substantially uniformly dispersed in the excipient matrix. A method for forming a storage stable pantoprazole composition is also provided. The method includes combining a bulking agent and water to form a first solution, combining a pantoprazole and the first solution to form a second solution, combining sodium hydroxide and the second solution to form a bulk solution, and removing water from the bulk solution by drying to form the storage stable pantoprazole composition.