2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF

Compounds are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloid...

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Hauptverfasser: Vasconcelos Dias de Pinho e Melo, Teresa Margarida, Nascimento, Bruno Filipe Oliveira, Lopes, Ana Lúcia Cabral Cardos, Pontes Meireles Ferreira de Brito, Rui Manuel, Vieira Simões, Carlos José, Lourenço de Almeida, Zaida Catarina, Victor, Bruno Lourenço da Silva
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Sprache:eng
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Zusammenfassung:Compounds are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).