FGF-21 CONJUGATE FORMULATIONS

FGF-21 CONJUGATE FORMULATIONS

The present application provides pharmaceutical formulations comprising PEGylated FGF-21, e.g., a FGF-21 conjugate, and one or more stabilizers such as the chelator DPTA. The formulations can be can further stabilized by including a surfactant such as polysorbate 80 and/or adjusting the pH to about...

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Hauptverfasser: KHOSSRAVI, Mehrnaz, PATKE, Sanket, PALM, Thomas
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator KHOSSRAVI, Mehrnaz
PATKE, Sanket
PALM, Thomas
description The present application provides pharmaceutical formulations comprising PEGylated FGF-21, e.g., a FGF-21 conjugate, and one or more stabilizers such as the chelator DPTA. The formulations can be can further stabilized by including a surfactant such as polysorbate 80 and/or adjusting the pH to about 7.1. Also provided are methods of manufacture, methods of treatment, and kits.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title FGF-21 CONJUGATE FORMULATIONS
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