FGF-21 CONJUGATE FORMULATIONS

The present application provides pharmaceutical formulations comprising PEGylated FGF-21, e.g., a FGF-21 conjugate, and one or more stabilizers such as the chelator DPTA. The formulations can be can further stabilized by including a surfactant such as polysorbate 80 and/or adjusting the pH to about...

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Bibliographische Detailangaben
Hauptverfasser: KHOSSRAVI, Mehrnaz, PATKE, Sanket, PALM, Thomas
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present application provides pharmaceutical formulations comprising PEGylated FGF-21, e.g., a FGF-21 conjugate, and one or more stabilizers such as the chelator DPTA. The formulations can be can further stabilized by including a surfactant such as polysorbate 80 and/or adjusting the pH to about 7.1. Also provided are methods of manufacture, methods of treatment, and kits.