COATED DRUG COMPOSITIONS AND METHODS OF PREPARING THE SAME

COATED DRUG COMPOSITIONS AND METHODS OF PREPARING THE SAME

A pharmaceutical composition containing a metal oxide coated particle comprising 1) an amorphous solid dispersion (ASD) core containing an active pharmaceutical ingredient (API) and a polymer; and 2) a metal oxide coating, and the method of making said metal oxide coated particle by atomic layer dep...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Fei, Chiruvolu, Shivkumar, Narwankar, Pravin K, Ganapathy, Balaji, Wang, Miaojun, Frankel, Jonathan
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A pharmaceutical composition containing a metal oxide coated particle comprising 1) an amorphous solid dispersion (ASD) core containing an active pharmaceutical ingredient (API) and a polymer; and 2) a metal oxide coating, and the method of making said metal oxide coated particle by atomic layer deposition (ALD). The metal oxide coated particle is useful because it prevents the ASD from crystallization and helps maintain the ASD in an amorphous form.