PHARMACEUTICAL COMPOSITION CONTAINING DABIGATRAN ETEXILATE AND PREPARATION METHOD THEREOF

PHARMACEUTICAL COMPOSITION CONTAINING DABIGATRAN ETEXILATE AND PREPARATION METHOD THEREOF

Disclosed is a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises a pharmaceutically active ingredient, dabigatran etexilate and/or dabigatran etexilate mesylate, and an polymer of polyvinyl caprolactam-polyvinyl acet...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG, Danyong, ZHAO, Wenfang, JIAO, Yan, ZHANG, Shizhong, SHI, Jingmin, DONG, Liang Chang
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Disclosed is a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises a pharmaceutically active ingredient, dabigatran etexilate and/or dabigatran etexilate mesylate, and an polymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. The mass ratio of the two is 1:0.23 to 1:3. The pharmaceutical composition not only increases the bioavailability of the pharmaceutically active ingredient, but also reduces absorption variability, and provides a more stable concentration of dabigatran in plasma, thereby reducing adverse side effects.