NOVEL DERIVATIVE OF BETA-APOPICROPODOPHYLLIN AND METHOD OF PREPARING THEREOF

NOVEL DERIVATIVE OF BETA-APOPICROPODOPHYLLIN AND METHOD OF PREPARING THEREOF

Provided are a novel derivative of β-apopicropodophyllin and a method of preparing the same, and more particularly, a compound represented by Formula 1 below, which is a novel derivative of β-apopicropodophyllin derived from podophyllotoxin, which is an anticancer agent, a method of preparing the sa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: NAM, So-Yeon, CHOI, Jong-Ryoo, CHOI, In-Young, HYUN, Se Hee
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Provided are a novel derivative of β-apopicropodophyllin and a method of preparing the same, and more particularly, a compound represented by Formula 1 below, which is a novel derivative of β-apopicropodophyllin derived from podophyllotoxin, which is an anticancer agent, a method of preparing the same, and a composition for treating cancer, which includes the compound.In Formula 1, R is a C2 to C10 alkyl group, a C2 to C10 alkyl group containing an allyl- or alkyne, a -[CH2]n-C3 to C8 cycloalkyl group, a substituted or unsubstituted -[CH2]n-phenyl group, a substituted or unsubstituted -[CH2]n-C5 to C6 heteroaromatic group, a -C(═O)-C1 to C8 alkyl group, a substituted or unsubstituted -C(═O)-[CH2]n-phenyl group, or a substituted or unsubstituted -C(═O)-[CH2]n-C5 to C6 heteroaromatic group, wherein n is an integer of 0 to 6.