POLYPROLINE MIMETICS OF PROLINE-DERIVED MODULE-15

The present invention relates to chemical compounds which can be used in particular as structural mimetics of proline-rich peptides. The compounds of the present invention are capable of selectively inhibiting Ena/VASP-EVH1-mediated protein-protein interactions. The invention further relates to the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Müller, Matthias, Dohmen, Stephan, Schmalz, Hans-Günther, Kühne, Ronald, Barone, Matthias, Albat, Dominik, Chiha, Slim
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention relates to chemical compounds which can be used in particular as structural mimetics of proline-rich peptides. The compounds of the present invention are capable of selectively inhibiting Ena/VASP-EVH1-mediated protein-protein interactions. The invention further relates to the use of these compounds as pharmaceutical agents and the use of the pharmaceutical agents for the treatment of tumor diseases.