MESOTHELIN AND CD137 BINDING MOLECULES

The present invention relates to antibody molecules that bind both mesothelin (MSLN) and CD137. The antibody molecules comprise a CDR-based binding site for MSLN, and a CD137 antigen-binding site located in a constant domain of the antibody molecule. The antibody molecules find application in the tr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wollerton, Francisca, Tuna, Mihriban, Brewis, Neil, Fertin, Remi, Munoz-Olaya, Jose, Reader, Claire
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to antibody molecules that bind both mesothelin (MSLN) and CD137. The antibody molecules comprise a CDR-based binding site for MSLN, and a CD137 antigen-binding site located in a constant domain of the antibody molecule. The antibody molecules find application in the treatment of cancer, for example.