NOVEL SESQUITERPENOID ANALOGS

The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitiz...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Adibekian, Alexander, Dai, Mingji, Zhang, Zhong-Yin, Hoch, Dominic Gregor, Davis, Dexter Cameron
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging thugs for cancers.