MSC- AND EXOSOME-BASED IMMUNOTHERAPY

Compositions comprising at least one of miR that down regulates PD-L1/PD-1, MSCs expressing same, or exosomes from those MSCs are provided. Methods of decreasing PD-L1 expression, PD-1 expression or both and treating PD-L1 positive cancers using same are also provided.

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Bibliographische Detailangaben
Hauptverfasser: BRODIE, Chaya, BRODIE, Aharon
Format: Patent
Sprache:eng
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Zusammenfassung:Compositions comprising at least one of miR that down regulates PD-L1/PD-1, MSCs expressing same, or exosomes from those MSCs are provided. Methods of decreasing PD-L1 expression, PD-1 expression or both and treating PD-L1 positive cancers using same are also provided.