METHODS OF TREATING AUTOIMMUNE DISEASE OR CHRONIC INFLAMMATION WITH ANTIBODIES THAT BIND AND BLOCK TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1 (TREM-1)

METHODS OF TREATING AUTOIMMUNE DISEASE OR CHRONIC INFLAMMATION WITH ANTIBODIES THAT BIND AND BLOCK TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1 (TREM-1)

The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid ar...

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Bibliographische Detailangaben
Hauptverfasser: WIBERG, Charlotte, STENNICKE, Vibeke Westphal, SALBO, Rune, GRELL, Susanne Nedergaard, READ, Christine Brender, PADKJAER, Soeren, HENRIKSEN, Anette
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.