PEPTIDE HAVING HIGH AFFINITY FOR PD-L1 PROTEIN AND USE THEREOF

PEPTIDE HAVING HIGH AFFINITY FOR PD-L1 PROTEIN AND USE THEREOF

The present invention provides a peptide having high binding affinity for PD-L1 protein and use thereof. The peptide has an amino acid sequence of SEQ. ID. NO. 1, SEQ. ID. NO. 3 or SEQ. ID. NO. 4, or the peptide is a tandem or branched peptide with a single repeat or multiple repeats of SEQ. ID. NO....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zhu, Naishuo, Liu, Baoxiu
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention provides a peptide having high binding affinity for PD-L1 protein and use thereof. The peptide has an amino acid sequence of SEQ. ID. NO. 1, SEQ. ID. NO. 3 or SEQ. ID. NO. 4, or the peptide is a tandem or branched peptide with a single repeat or multiple repeats of SEQ. ID. NO. 1, SEQ. ID. NO. 3 and SEQ. ID. NO. 4 and has an amino acid sequence of SEQ. ID. NO. 5. The peptide can bind to human PD-L1 with high affinity, competitively block the affinity of PD-1/PD-L1 protein, block the negative regulatory tolerance pathway of human tumors, activate immunity and increase the lethality of T cells against tumor cells.