PHARMACEUTICAL COMPOSITION COMPRISING MESENCHYMAL STEM CELLS AS EFFECTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF INFLAMMATORY DISEASE

PHARMACEUTICAL COMPOSITION COMPRISING MESENCHYMAL STEM CELLS AS EFFECTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF INFLAMMATORY DISEASE

A pharmaceutical composition comprising HLA-A2-expressing mesenchymal stem cells as an effective ingredient and its use in prevention or treatment of inflammatory disease are disclosed. The mesenchymal stem cells expressing HLA-A2 on the surface thereof inhibit the secretion of the inflammatory cyto...

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Bibliographische Detailangaben
Hauptverfasser: YANG, Yun Sun, KIM, Dong Hyon, LIM, Hoon, OH, Wonil, CHOI, Soo Jin, KWAK, Jihye
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A pharmaceutical composition comprising HLA-A2-expressing mesenchymal stem cells as an effective ingredient and its use in prevention or treatment of inflammatory disease are disclosed. The mesenchymal stem cells expressing HLA-A2 on the surface thereof inhibit the secretion of the inflammatory cytokine TNF-a and increase the expression of the anti-inflammatory markers CD163 and Arg-1, so that the pharmaceutical composition comprising the mesenchymal stem cells as an effective ingredient can be advantageously used for suppressing inflammation or treating inflammatory diseases.