CH3 DOMAIN EPITOPE TAGS
This invention relates to the incorporation of one, or more, heterologous antibody epitopes into the AB, EF, or CD structural loops of the constant heavy domain 3 ("CH3 domain") of an engineered antibody or Fc-linked therapeutic agent. The heterologous epitopes serve as "epitope tags&...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | This invention relates to the incorporation of one, or more, heterologous antibody epitopes into the AB, EF, or CD structural loops of the constant heavy domain 3 ("CH3 domain") of an engineered antibody or Fc-linked therapeutic agent. The heterologous epitopes serve as "epitope tags" that are specifically detectable by epitope tag-specific detector antibodies, irrespective of the tagged agent's target specificity. Therefore, the epitope tags are useful for the rapid detection of any tagged antibody or Fc-linked agent in biological samples, including samples, which also contain endogenous antibodies. |
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