INHIBITORS OF GLUCOSE TRANSPORTERS (GLUTs)

INHIBITORS OF GLUCOSE TRANSPORTERS (GLUTs)

The present invention relates to 2,6-methanobenzo[g][l]oxacin-4-onecompounds and their analog compounds and pharmaceutically acceptable salts thereof as selective inhibitor of glucose transporters 1 and 3 (GLUTs 1 and 3), to methods of preparing said compounds, and to the use thereof as pharmaceutic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nussbaumer, Peter, Reckzeh, Elena Sabrina, Ziegler, Slava, Zischinsky, Gunther, Cerrajeria, Javier de Ceballos, Waldmann, Herbert, Schwalfenberg, Melanie, Karageorgis, George
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to 2,6-methanobenzo[g][l]oxacin-4-onecompounds and their analog compounds and pharmaceutically acceptable salts thereof as selective inhibitor of glucose transporters 1 and 3 (GLUTs 1 and 3), to methods of preparing said compounds, and to the use thereof as pharmaceutically active agents, especially for the prophylaxis and/or treatment of metabolic diseases, immunological diseases, autoimmune diseases, inflammation, graft versus host disease, cancer, and metastasis thereof. Furthermore, the present invention is directed to pharmaceutical composition comprising at least one of 2,6-methanobenzo[g][l]oxacin-4-one compounds and their analog compounds.