Accurate Sensing of Physiological Substance in Blood

A sensor arrangement for detecting information indicative of a physiological substance in blood of a physiological subject, wherein the sensor arrangement has a first sensor structure configured for electrochemically sensing the physiological substance in at least part of the blood, wherein detecting the physiological substance is influenceable by hemolysis of the blood, a second sensor structure configured for electrochemically sensing a parameter in at least part of the blood, which parameter is indicative of hemolysis of the blood, and a plasma separation unit configured for separating plasma from the blood and arranged so that the separated plasma is supplied to the first sensor structure and the second sensor structure, whereas a rest of the blood is kept apart from the first sensor structure and the second sensor structure.